Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels.docVIP

Klug et al. Genome Biology 2010, 11:R63 /2010/11/6/R63 RESEARCH Open Access Active DNA demethylation in human postmitotic Research cells correlates with activating histone modifications, but not transcription levels Maja Klug1, Sven Heinz2, Claudia Gebhard1, Lucia Schwarzfischer1, Stefan W Krause3, Reinhard Andreesen1 and Michael Rehli*1 Abstract Background: In mammals, the dynamics of DNA methylation, in particular the regulated, active removal of cytosine methylation, has remained a mystery, partly due to the lack of appropriate model systems to study DNA demethylation. Previous work h