Adenine oxidation by pyrite-generated hydroxyl radicals.docVIP

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Adenine oxidation by pyrite-generated hydroxyl radicals.doc

Adenine oxidation by pyrite-generated hydroxyl radicals

Cohnetal.GeochemicalTransactions2010,11:2 /content/11/1/2 RESEARCH ARTICLE OpenAccess Adenineoxidationbypyrite-generatedhydroxyl radicals CoreyACohn1,3,ShawnCFisher2,BruceJBrownawell2,MartinAASchoonen1* Abstract Cellularexposuretoparticulatematterwithconcomitantformationofreactiveoxygenspecies(ROS)andoxidiza- tionofbiomoleculesmayleadtonegativehealthoutcomes.Evaluatingtheparticle-inducedformationofROSand theoxidationproductsfromreactionofROSwithbiomoleculesisusefulforgainingamechanisticunderstanding ofparticle-inducedoxidativestress.Aqueoussuspensionsofpyriteparticleshavebeenshowntoformhydr

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