原创力文档Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.docVIP
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Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells
Hammarstedtetal.DiabetologyMetabolicSyndrome2012,4:42
/content/4/1/42
DIABETOLOGY
METABOLIC SYNDROME
RESEARCH
OpenAccess
Adiposetissuedysregulationandreducedinsulin
sensitivityinnon-obeseindividualswithenlarged
abdominaladiposecells
AnnHammarstedt1*,TimothyEGraham2andBarbaraBKahn2
Abstract
Background:ObesitycontributestoType2diabetesbypromotingsystemicinsulinresistance.Obesitycauses
featuresofmetabolicdysfunctionintheadiposetissuethatmaycontributetolaterimpairmentsofinsulinactionin
skeletalmuscleandliver;theseincludereducedinsulin-stimulatedglucosetransport,reducedexpressionofGLUT4,
altere
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