Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation.docVIP

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Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation.doc

Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation

AhKioonetal.ArthritisResearchTherapy2010,12:R190 /content/12/5/R190 RESEARCH ARTICLE OpenAccess Adrenomedullinincreasesfibroblast-like synoviocyteadhesiontoextracellularmatrix proteinsbyupregulatingintegrinactivation Marie-DominiqueAhKioon1,2,CarineAsensio1,2,Hang-KorngEa1,2,3,BenjaminUzan1,2,MartineCohen-Solal1,2,3, FrédéricLioté1,2,3* Abstract Introduction:Rheumatoidarthritis(RA)ischaracterizedbyboneandcartilageinvasionbyfibroblast-like synoviocytes(FLSs).Adrenomedullin,apeptidewithanabolicandantiapoptoticproperties,issecretedby rheumatoidFLSs.Adrenomedullinalsoincreasestheexpressionofadh

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Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation.docVIP