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Advanced brain dopamine transporter imaging in mice using small-animal SPECTCT
Pitkonenetal.EJNMMIResearch2012,2:55
/content/2/1/55
ORIGINAL RESEARCH
OpenAccess
Advancedbraindopaminetransporterimagingin
miceusingsmall-animalSPECT/CT
MiiaPitkonen1?,EeroHippel?inen2,5?,MariRaki1,Jaan-OlleAndressoo3,ArtoUrtti1,PekkaTM?nnist?4,
SauliSavolainen5,MartSaarma3andKimBergstr?m1*
Abstract
Background:Iodine-123-β-CIT,asingle-photonemissioncomputedtomography(SPECT)ligandfordopamine
transporters(DATs),hasbeenusedforinvivostudiesinhumans,monkeys,andratsbuthasnotyetbeenused
extensivelyinmice.TovalidatetheimagingandanalysismethodsforpreclinicalDATimaging,wild-typehealthy
micewerescann
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