Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.docVIP

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Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.doc

Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis

Hannaetal.Alzheimer?’?sResearchTherapy2012,4:21 /content/4/3/21 RESEARCH OpenAccess Age-relatedincreaseinamyloidplaqueburdenis associatedwithimpairmentinconditionedfear memoryinCRND8mousemodelofamyloidosis AmandaHanna2,KayleighIremonger3,PritamDas2,DennisDickson2,ToddGolde1andChristopherJanus1* Abstract Introduction:ThecurrentpathologicalconfirmationofthediagnosisofAlzheimer’sdisease(AD)isstillbasedon postmortemidentificationofparenchymalamyloidbeta(Ab)plaques,intra-neuronalneurofibrillarytangles,and neuronalloss.ThememorydeficitsthatarepresentintheearlystagesofADarelinkedtothedysfunctionof

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Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis.docVIP