An epigenomic mechanism in retinoblastoma the end of the story.docVIP

Murphree and Triche Genome Medicine 2012,4:15 /content/4/2/15 RESEARCH HIGHLIGHT An epigenomic mechanism in retinoblastoma: the end of the story? A Linn Murphree * and Timothy J Triche 1 2 usually discovered in the retinas of infants with a family history of the disease, are always the same - small, soft, round, intraretinal, gray-white ‘clones’ - as if they were daughter cells arising from a single cell with identical growth characteristics. As these ‘clones’ grow, asym- metrical overgrowth app