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An FPT haplotyping algorithm on pedigrees with a small number of sites
DoanandEvansAlgorithmsforMolecularBiology2011,6:8
/content/6/1/8
RESEARCH
OpenAccess
AnFPThaplotypingalgorithmonpedigreeswith
asmallnumberofsites
DuongDDoanandPatriciaAEvans*
Abstract
Background:Geneticdiseasestudiesinvestigaterelationshipsbetweenchangesinchromosomesandgenetic
diseases.Singlehaplotypesprovideusefulinformationforthesestudiesbutextractingsinglehaplotypesdirectlyby
biochemicalmethodsisexpensive.Acomputationalmethodtoinferhaplotypesfromgenotypedataistherefore
important.Weinvestigatetheproblemofcomputingtheminimumnumberofrecombinationeventsforgeneral
pedigreeswithasmallnumberofsi
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