An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog).docVIP

Molecules 2001, 6, 959-963 molecules ISSN 1420-3049 An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenyl- ? thio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog) Matthias Treu 1 , Ulrich Jordis and Ving J. Lee *,1 2 1 2 Institute of Organic Chemistry, VUT, A-1060 Vienna, Getreidemarkt 9, Austria Iconix Pharmaceuticals, Inc., 830 Maude Avenue, Mountain View, CA 94043 ? This paper was presented at the Fifth Electronic Conference on Synthetic Organic Chemistry (ECSOC-5), September 1-30, 2001 (Paper A0039). * Author to whom correspondence shoul