APCAP - activated protein C in acute pancreatitis a double-blind randomized human pilot trial.docVIP

Pettil?etal.CriticalCare2010,14:R139 /content/14/4/R139 RESEARCH OpenAccess APCAP-activatedproteinCinacutepancreatitis: adouble-blindrandomizedhumanpilottrial VillePettil?1,2*,LeaKyh?l?3,Marja-LeenaKyl?np??3,AriLepp?niemi3,MinnaTallgren1,AnttiMarkkola4, PauliPuolakkainen3,HeikkiRepo5,6,EskoKemppainen3 Abstract Introduction:PrevioushumanstudieshaveshownlowactivityofproteinC(APC)insevereacutepancreatitis (SAP).This,togetherwiththefindingsinanimalmodels,suggeststhatactivatedproteinC(APC)mayprotect againstpancreaticinjuryandamelioratethedisease.We,therefore,evaluateditseffectonmultipleorgan dysf