原创力文档Antipsychotic medications and cognitive functioning in bipolar disorder moderating effects of COMT Val108158 Met genotype.docVIP
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Antipsychotic medications and cognitive functioning in bipolar disorder moderating effects of COMT Val108158 Met genotype
Artsetal.BMCPsychiatry2013,13:63
/1471-244X/13/63
RESEARCH ARTICLE
OpenAccess
Antipsychoticmedicationsandcognitive
functioninginbipolardisorder:moderating
108/158
effectsofCOMTVal
Metgenotype
BaerArts1*,ClaudiaJPSimons1,2,MarjanDrukker1andJimvanOs1,3
Abstract
Background:Thereisanegativeassociationbetweentheuseofantipsychoticsandcognitivefunctioningin
bipolarpatients,whichmaybemediatedbyaltereddopaminesignalinginselectedbrainareas,andmoderation
thereofbygeneticsequencevariationsuchasCOMTVal108/158Met.Theinteractionbetweenantipsychoticdruguse
andtheCOMTVal108/158Metgenotypeontwo-yearcognitive
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