原创力文档Aquaporins relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus.docVIP
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Aquaporins relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus
Brianetal.CerebrospinalFluidResearch2010,7:15
/content/7/1/15
CEREBROSPINAL FLUID RESEARCH
REVIEW
OpenAccess
Aquaporins:relevancetocerebrospinalfluid
physiologyandtherapeuticpotentialin
hydrocephalus
OwlerKBrian1,2,3*,PithamTom1,DongweiWang1
Abstract
Thediscoveryofafamilyofmembranewaterchannelproteinscalledaquaporins,andthefindingthataquaporin
1waslocatedinthechoroidplexus,haspromptedinterestintheroleofaquaporinsincerebrospinalfluid(CSF)
productionandconsequentlyhydrocephalus.Whiletheroleofaquaporin1inchoroidalCSFproductionhasbeen
demonstrated,therelevanceofaquaporin1tothepathophysiologyofh
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