Applications of Olefination Reactions to Cassiol Synthesis.docVIP

327 Molecules 2000, 5 Applications of Olefination Reactions to Cassiol Synthesis María I. Colombo, Jose A. Bacigaluppo, Mirta P. Mischne, Juán Zinczuk and Edmundo A. Rú- veda Instituto de Química Orgánica de Síntesis (IQUIOS-UNR) Casilla de Correo 991, 2000 Rosario, Ar- gentina E-mail: iquiosra@citynet.net.ar Abstract: Olefination reactions directed to the synthesis of cassiol from compounds 2-5 will be discussed. Introduction Cassiol (1), which exhibits a potent antiulcer activity, contains a functionalized cyclohexenone mo- eity with a quaternary stereogenic center at C-4 and a 2-vin