Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I Four Case Studies.docVIP

Pharmaceutics 2011, 3, 582-600; doi:10.3390/pharmaceutics3030582 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Article Application of Twin Screw Extrusion in the Manufacture of Cocrystals, Part I: Four Case Studies Dominick Daurio, Cesar Medina, Robert Saw, Karthik Nagapudi * and Fernando Alvarez-Nú?ez * Small Molecule Process and Product Development, Amgen Inc, Thousand Oaks, CA 91320, USA * Authors to whom correspondence should be addressed; E-Mails: karthikn@ (K.N.); faalvare@ (F.A.-N.); Tel.: +1-805-313-5023; Fax: +1-805-447-3259. Received: 1 July 2011; in