原创力文档Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.docVIP
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Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis
Larssonetal.ArthritisResearchTherapy2010,12:R230
/content/12/6/R230
RESEARCH ARTICLE
OpenAccess
Associationbetweensynovialfluidlevelsof
aggrecanARGSfragmentsandradiographic
progressioninkneeosteoarthritis
StaffanLarsson1*,MartinEnglund1,2,AndréStruglics1,LStefanLohmander1
Abstract
Introduction:Aggrecanasecleavageatthe 392Glu-393Alabondintheinterglobulardomain(IGD)ofaggrecan,
releasingN-terminal 393ARGSfragments,isanearlykeyeventinarthritisandjointinjuries.Wedeterminedwhether
synovialfluid(SF)levelsofARGS-aggrecandistinguishsubjectswithprogressiveradiographickneeosteoarthritis
(ROA)fromt
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