Bacillus Coagulans GBI-30 (BC30) improves indices of Clostridium difficile-Induced colitis in mice.docVIP

Fitzpatricketal.GutPathogens2011,3:16 /content/3/1/16 RESEARCH OpenAccess BacillusCoagulansGBI-30(BC30)improvesindices ofClostridiumdifficile-Inducedcolitisinmice LeoRFitzpatrick1*,JeffreySSmall1,WallaceHGreene2,KellyDKarpa1andDavidKeller3 Abstract Background:ProbioticshavebeneficialeffectsinrodentmodelsofClostridiumdifficile(C.diffiicle)-inducedcolitis. ThesporeformingprobioticstrainBacillusCoagulansGBI-30,6086(BC30)hasdemonstratedanti-inflammatoryand immune-modulatingeffectsinvitro.OurgoalwastodetermineifBC30improvedC.difficile-inducedcolitisinmice. Startingonstudyday0,femaleC57BL/6micewer