B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy.docVIP

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B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy.doc

B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy

Catalánetal.ArthritisResearchTherapy2010,12:R68 /content/12/2/R68 RESEARCH ARTICLE OpenAccess Bcellsfromrheumatoidarthritispatientsshow importantalterationsintheexpressionofCD86 andFcgRIIb,whicharemodulatedbyanti-tumor necrosisfactortherapy DiegoCatalán1,OctavioAravena1,FranciscaSabugo2,PamelaWurmann2,LilianSoto2,AlexisMKalergis3, MiguelCuchacovich2,JuanCAguillón1*,MilleniumNucleusonImmunologyandImmunotherapyP-07-088-F Abstract Introduction:SeveralmoleculeshelppreserveperipheralBcelltolerance,butwhenaltered,theymaypredispose toautoimmunity.Thisworkstudiedtheexpressionofthecostimulatorymolec

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B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcγRIIb, which are modulated by anti-tumor necrosis factor therapy.docVIP