Bacterial epidemiology and biology - lessons from genome sequencing.docVIP

Parkhill and Wren Genome Biology 2011,12:230 /2011/12/10/230 RE VIE W Bacterial epidemiology and biology - lessons from genome sequencing Julian Parkhill and Brendan W Wren * 1 2 highly informative, they have limited resolution when applied to closely related isolates. us, they are often unsuitable for identifying ?ne-grained evolutionary events or for distinguishing clonal strains within a recent epidemic [10]. is situation has now been improved by the application of next-generation sequencing to