药理学-李庆平-抗肿瘤药.pptVIP

抗恶性肿瘤药 Antineoplastic Drugs Neoplasms New or unusual growth of tissue, tumors May be benign or malignant (cancer) Cancer Cells Tend to rapidly proliferate or increase in number Results in morbidity (sickness) and mortality (death) Original site of tumor—primary site Tumors may spread or metastasize Each new site—secondary site 恶性肿瘤的治疗 三大手段：Surgery, radiation therapy, chemotherapy，从姑息性目的向根治目标迈进 Antineoplastics work better on rapidly growing tumors 目前临床上约5％的恶性肿瘤可通过化疗治愈 但占所有肿瘤中90％的实体瘤治疗效果不佳 肿瘤化疗的历史 殷墟甲骨文-----瘤 古埃及：砷化物油膏治疗皮肤癌 1865年Lissauer亚砷酸溶液治疗慢性白血病 1939年激素用于乳腺癌、前列腺癌的治疗 1943年“巴里灾难”，氮芥成功治疗淋巴肉瘤