Biochemical tolerance during low dose propylene glycol exposure in neonates A formulation-controlled evaluation.docVIP

Kuloetal.DARUJournalofPharmaceuticalSciences2012,20:5 /content/20/1/5 RESEARCH ARTICLE OpenAccess Biochemicaltoleranceduringlowdosepropylene glycolexposureinneonates:A formulation-controlledevaluation AidaKulo1,2,AnneSmits3,GunnarNaulaers3,JandeHoon1andKarelAllegaert3,4* Abstract Backgroundandpurposeofthestudy:Propyleneglycol(PG)isafrequentlyco-administeredsolventinformulations administeredtoneonates,butreportsonits(in)tolerancearelimited.Weaimedtoreportonrenal,metabolicand hepatictolerancebefore,duringandfollowingintravenous(iv)PG-paracetamolexposureandcomparedthesedatawith similardatasets