Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyteagarose constructs.docVIP

Chowdhury et al. Arthritis Research Therapy 2010, 12:R82 /content/12/3/R82 RESEARCH ARTICLE Open Access Biomechanical modulation of collagen Research article fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs Tina T Chowdhury*1, Ronny M Schulz2, Sonpreet S Rai1, Christian B Thuemmler2, Nico Wuestneck2, Augustinus Bader2 and Gene A Homandberg3 Abstract Introduction: The present study examined the effect of collagen fragments on anabolic and catabolic activities by chondrocyte/agarose constructs subjected to dynamic compression. Methods: Constructs were