Blood substitutes Haemoglobin therapeutics in clinical practice.docVIP

Mini-review R99 Blood substitutes Haemoglobin therapeutics in clinical practice Jean-Fran?ois Baron Early approaches to the development of oxygen carriers involved the use of stroma-free hemoglobin solutions. These solutions did not require blood typing or crossmatching and could be stored for long periods. In addition, a variety of methods have been developed in chemically modifying and stabilizing the hemoglobin molecule. Several hemoglobin therapeutics are now in clinical trials as temporary alternatives to blood or as therapeutic agents for ischemia. The various hemoglobin products under