Bradykinin and the Pathogenesis of Hereditary Angioedema.docVIP

NOTES OFALLERGYWATCHERS BradykininandthePathogenesisofHereditaryAngioedema AllenP.Kaplan,MD H ereditary angioedema (HAE) is a term coined for a familialformofpotentiallylife-threateningangioedema (activated Hageman factor) and activation of the complement cascadesothatsimultaneousproductionofbradykinin(inhibited byFactorXIIactivation)andtheC2-kininseemedpossible. Duringtheyears1972–1990Iwasstudyingthemech- anism of activation of the plasma bradykinin cascade. Two formsofactivatedFactorXIIweredescribed,thatis,Factor XIIaatabout80kdandFactorXIIfragment(XIIf)at28.5–30 ?rstdescribedbyWilliamOsle