BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer.docVIP

vanRoonetal.ClinicalEpigenetics2013,5:2 /content/5/1/2 RESEARCH OpenAccess BRAFmutation-specificpromotermethylationof FOXgenesincolorectalcancer EddyHvanRoon1,2,ArnoudBoot1,2,AshwinADihal1,2,RobertFErnst3,TomvanWezel2,HansMorreau2 andJudithMBoer1,3,4* Abstract Background:Cancer-specifichypermethylationof(promoter)CpGislandsiscommonduringthetumorigenesisof coloncancer.Althoughassociationsbetweencertaingeneticaberrations,suchasBRAFmutationandmicrosatellite instability,andtheCpGislandmethylatorphenotype(CIMP),havebeenfound,themechanismsbywhichthese associationsareestablishedarestillunclear.West