Caging the Beast TRIM5α Binding to the HIV-1 Core.docVIP

Viruses 2011, 3, 423-428; doi:10.3390/v3050423 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Commentary Caging the Beast: TRIM5? Binding to the HIV-1 Core Felipe Diaz-Griffero Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; E-Mail: Felipe.Diaz-Griffero@; Tel.: +1-(718)-678-1191; Fax: +1-(718)-632-4338 Received: 16 March 2011; in revised form: 21 April 2011 / Accepted: 21 April 2011 / Published: 27 April 2011 Abstract: The potent HIV-1 inhibitor TRIM5? blocks HIV-1 infection by accelerating the uncoating of HIV-1. TRIM5? is k