Calyculin A from Discodermia Calyx Is a Dual Action Toxin that Blocks Calcium Influx and Inhibits Protein SerThr Phosphatases.docVIP

Toxins 2012, 4, 940-954; doi:10.3390/toxins4100940 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article Calyculin A from Discodermia Calyx Is a Dual Action Toxin that Blocks Calcium Influx and Inhibits Protein Ser/Thr Phosphatases Maja Holy 1,2 and David L. Brautigan 1,2, * 1 Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; E-Mail: mh5yu@ 2 Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22910, USA * Author to whom correspondence should be addressed; E-Ma