Cancer genomics identifies determinants of tumor biology.docVIP

Mardis Genome Biology 2010, 11:211 /2010/11/5/211 RE VIE W Cancer genomics identi?es determinants of tumor biology Elaine R Mardis* In this review, I will describe some tumor-speci?c altera- Abstract tions that were discovered as a result of analyses of Unbiased sequencing and analysis of human tumors is revealing unsuspected somatic changes that, upon further study, are elucidating aspects of tumor biology and identifying new biomarkers. unbiased genome or transcriptome sequencing data (unbiased sequencing does not select for portions of the genome or transcript