Capturing Alzheimers disease genomes with induced pluripotent stem cells prospects and challenges.docVIP

Israel and Goldstein Genome Medicine 2011,3:49 /content/3/7/49 RE VIE W Capturing Alzheimer’s disease genomes with induced pluripotent stem cells: prospects and challenges Mason A Israel* and Lawrence SB Goldstein* fully recapitulate AD pathogenesis. Consequently, it has Abstract been very di?cult to elucidate the initiating events of A crucial limitation to our understanding of Alzheimer’s disease (AD) is the inability to test hypotheses on live, patient-specic neurons. Patient autopsies are limited in supply and only reveal endpoints of disease. Rodent models harboring familia