原创力文档Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3.docVIP
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Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
Frietzeetal.GenomeBiology2012,13:R52
/content/13/9/R52
RESEARCH
OpenAccess
Celltype-specificbindingpatternsrevealthat
TCF7L2canbetetheredtothegenomeby
associationwithGATA3
SethFrietze1?,RuiWang2,3?,LijingYao1,YuGyoungTak1,ZhenqingYe3,MalainaGaddis1,HeatherWitt1,
PeggyJFarnham1* andVictorXJin3*
Abstract
Background:TheTCF7L2transcriptionfactorislinkedtoavarietyofhumandiseases,includingtype2diabetes
andcancer.OnemechanismbywhichTCF7L2couldinfluenceexpressionofgenesinvolvedindiversediseasesis
bybindingtodistinctregulatoryregionsindifferenttissues.Totestthishypothesis,weperformedChIP-seqfor
TCF7
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