Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome.docVIP

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Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome.doc

Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome

McLaughlinandChadwickGenomeBiology2011,12:R37 /2011/12/4/R37 RESEARCH OpenAccess CharacterizationofDXZ4conservationin primatesimpliesimportantfunctionalrolesfor CTCFbinding,arrayexpressionandtandem repeatorganizationontheXchromosome ChristineRMcLaughlinandBrianPChadwick* Abstract Background:Comparativesequenceanalysisisapowerfulmeanswithwhichtoidentifyfunctionallyrelevantnon- codingDNAelementsthroughconservednucleotidesequence.ThemacrosatelliteDXZ4isapolymorphic, uninterrupted,tandemarrayof3-kbrepeatunitslocatedexclusivelyonthehumanXchromosome.Whilenot obviouslyproteincoding,itschromatinorga

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Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome.docVIP