Chitosan and chitosan chlorhydrate based various approaches for enhancement of dissolution rate of carvedilol.docVIP

Sheteetal.DARUJournalofPharmaceuticalSciences2012,20:93 /content/20/1/93 RESEARCH ARTICLE OpenAccess Chitosanandchitosanchlorhydratebasedvarious approachesforenhancementofdissolutionrate ofcarvedilol AmolSShete1*,AdhikraoVYadav2andSrinivasaMMurthy3 Abstract Backgroundandthepurposeofthestudy:Carvedilolnonselectiveβ-adrenoreceptorblocker,chemically (±)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxypHenoxy)ethyl]amino]-2-propanol,slightlysolubleinethylether;and practicallyinsolubleinwater,gastricfluid(simulated,TS,pH1.1),andintestinalfluid(simulated,TSwithout pancreatin,pH7.5)Compoundswithaqueoussolubi