Chromosomal mapping, differential origin and evolution of the S100 gene family.docVIP

Genet.Sel.Evol.40(2008)449–464 óINRA,EDPSciences,2008 DOI:10.1051/gse:2008013 Availableonlineat: Originalarticle Chromosomalmapping,differentialorigin andevolutionoftheS100genefamily XuanSHANG,HanhuaCHENG*,RongjiaZHOU* DepartmentofGeneticsandCenterforDevelopmentalBiology,CollegeofLifeSciences, WuhanUniversity,Wuhan430072,P.R.China (Received13October2007;accepted21December2007) Abstract–S100 proteins are calcium-binding proteins, which exist only in vertebrates andwhichconstitutealargeproteinfamily.TheoriginandevolutionoftheS100family invertebratelineagesremainachallenge.Here,weexaminedthesy