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Chronic granulomatous disease, the McLeod phenotype and the contiguous gene deletion syndrome-a review.docVIP

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Chronic granulomatous disease, the McLeod phenotype and the contiguous gene deletion syndrome-a review.doc

    Chronic granulomatous disease, the McLeod phenotype and the contiguous gene deletion syndrome-a review

    Watkinsetal.ClinicalandMolecularAllergy2011,9:13 /content/9/1/13 CMA REVIEW OpenAccess Chronicgranulomatousdisease,theMcLeod phenotypeandthecontiguousgenedeletion syndrome-areview CaseyEWatkins1,JohnLitchfield2,EunkyungSong3,GayatriBJaishankar3,NivaMisra1,NikhilHolla2, MichelleDuffourc4andGuhaKrishnaswamy5* Abstract ChronicGranulomatousDisease(CGD),adisorderoftheNADPHoxidasesystem,resultsinphagocytefunctional defectsandsubsequentinfectionswithbacterialandfungalpathogens(suchasAspergillusspeciesandCandida albicans).Deletionsandmissense,frameshift,ornonsensemutationsinthegp91phox gene(als

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