Chronic granulomatous disease a review of the infectious and inflammatory complications.docVIP

Songetal.ClinicalandMolecularAllergy2011,9:10 /content/9/1/10 CMA REVIEW OpenAccess Chronicgranulomatousdisease:areviewofthe infectiousandinflammatorycomplications EunKyungSong1,GayatriBalaJaishankar1,HanaSaleh3,WaritJithpratuck3,RyanSahni3and GuhaKrishnaswamy1,2,3* Abstract ChronicGranulomatousDiseaseisthemostcommonlyencounteredimmunodeficiencyinvolvingthephagocyte, andischaracterizedbyrepeatedinfectionswithbacterialandfungalpathogens,aswellastheformationof granulomasintissue.ThediseaseistheresultofadisorderoftheNADPHoxidasesystem,culminatinginan inabilityofthephagocytetogeneratesuperoxide,