Chronic arthritis leads to disturbances in the bone collagen network.docVIP

Caetano-Lopes et al. Arthritis Research Therapy 2010, 12:R9 /content/12/1/R9 RESEARCH ARTICLE Open Access Chronic arthritis leads to disturbances in the bone Research article collagen network Joana Caetano-Lopes1, Ana M Nery1,2,3, Helena Canh?o1,4, Joana Duarte5,6, Rita Casc?o1, Ana Rodrigues1,4, Inês P Perpétuo1, Saba Abdulghani1, Pedro M Amaral2,3, Shimon Sakaguchi7, Yrj? T Konttinen8,9, Luís Gra?a5,6, Maria F Vaz2,3 and Jo?o E Fonseca*1,4 Abstract Introduction: In this study we used a mice model of chronic arthritis to evaluate if bone fragility induced by chronic inflammation is