Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences.docVIP
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Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences
Polyanovskyetal.AlgorithmsforMolecularBiology2011,6:25
/content/6/1/25
RESEARCH
OpenAccess
Comparativeanalysisofthequalityofaglobal
algorithmandalocalalgorithmforalignmentof
twosequences
ValeryOPolyanovsky1,MikhailARoytberg2andVladimirGTumanyan1*
Abstract
Background:Algorithmsofsequencealignmentarethekeyinstrumentsforcomputer-assistedstudiesof
biopolymers.Obviously,itisimportanttotakeintoaccountthe“quality”oftheobtainedalignments,i.e.how
closelythealgorithmsmanagetorestorethe“goldstandard”alignment(GS-alignment),whichsuperimposes
positionsoriginatingfromthesamepositioninthecommonancestorofth
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