Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences.docVIP

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Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences.doc

Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences

Polyanovskyetal.AlgorithmsforMolecularBiology2011,6:25 /content/6/1/25 RESEARCH OpenAccess Comparativeanalysisofthequalityofaglobal algorithmandalocalalgorithmforalignmentof twosequences ValeryOPolyanovsky1,MikhailARoytberg2andVladimirGTumanyan1* Abstract Background:Algorithmsofsequencealignmentarethekeyinstrumentsforcomputer-assistedstudiesof biopolymers.Obviously,itisimportanttotakeintoaccountthe“quality”oftheobtainedalignments,i.e.how closelythealgorithmsmanagetorestorethe“goldstandard”alignment(GS-alignment),whichsuperimposes positionsoriginatingfromthesamepositioninthecommonancestorofth

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