原创力文档Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides practical consequences for the future of gallium-68-PET.docVIP
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Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides practical consequences for the future of gallium-68-PET
Notnietal.EJNMMIResearch2012,2:28
/content/2/1/28
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Comparativegallium-68labelingofTRAP-,NOTA-,
andDOTA-peptides:practicalconsequencesfor
thefutureofgallium-68-PET
JohannesNotni1*,KarolinPohle1,2andHans-JürgenWester1
Abstract
Background:Currently, 68Ga-labeled1,4,7,10-tetraazacyclododecane-tetraaceticacid(DOTA)-peptidesarethemost
widelyusedclassof 68GaradiotracersforPET,althoughDOTAisnotoptimalfor 68Gacomplexation.Morerecently,
1,4,7-triazacyclononane-triaceticacid(NOTA)andparticularlytriazacyclononane-phosphinate(TRAP)chelatorshave
beenshowntopossesssupe
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