Comparative multi-omics systems analysis of Escherichia coli strains B and K-12.docVIP

Yoonetal.GenomeBiology2012,13:R37 /2012/13/5/R37 RESEARCH OpenAccess Comparativemulti-omicssystemsanalysisof EscherichiacolistrainsBandK-12 SungHoYoon1,Mee-JungHan2,3,HaeyoungJeong1,ChoongHoonLee1,4,5,Xiao-XiaXia2,Dae-HeeLee1, JiHoonShim1,SangYupLee2,6,TaeKwangOh7andJihyunFKim1,5* Abstract Background:Elucidationofagenotype-phenotyperelationshipiscriticaltounderstandanorganismatthewhole- systemlevel.Here,wedemonstratethatcomparativeanalysesofmulti-omicsdatacombinedwithacomputational modelingapproachprovideaframeworkforelucidatingthephenotypiccharacteristicsoforganismswhose genomesaresequenced