Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts.docVIP

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Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts.doc

Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts

KushnirandPinheiroBMCClinicalPharmacology2011,11:8 /1472-6904/11/8 RESEARCH ARTICLE OpenAccess Comparisonofrenaleffectsofibuprofenversus indomethacinduringtreatmentofpatentductus arteriosusincontiguoushistoricalcohorts AllaKushnir1,2?andJoaquimMBPinheiro1*? Abstract Background:Ibuprofentreatmentofpatentductusarteriosus(PDA)hasbeenshowntobeaseffectiveas indomethacininsmallrandomizedcontrolledtrials,withpossiblyfeweradverseeffects.However,adverserenal effectsofibuprofenhavebeennotedinsometrialsandsuspectedinourpractice. Thepurposeofthisstudywastoexaminewhetheribuprofenandindomethacintreatment

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Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts.docVIP