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Conserved rules govern genetic interaction degree across species
Kochetal.GenomeBiology2012,13:R57
/2012/13/7/R57
RESEARCH
OpenAccess
Conservedrulesgoverngeneticinteraction
degreeacrossspecies
ElizabethNKoch1,MichaelCostanzo2,3,JeremyBellay1,4,RaameshDeshpande1,KateChatfield-Reed5,
GordonChua5,GennaroD’Urso6,BrendaJAndrews2,3,CharlesBoone2,3 andChadLMyers1*
Abstract
Background:Syntheticgeneticinteractionshaverecentlybeenmappedonagenomescaleinthebuddingyeast
Saccharomycescerevisiae,providingafunctionalviewofthecentralprocessesofeukaryoticlife.Currently,
comprehensivegeneticinteractionnetworkshavenotbeendeterminedforotherspecies,andwethereforesought
tom
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