Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients.docVIP

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Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients.doc

Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients

Wangetal.DiagnosticPathology2013,8:5 /content/8/1/5 RESEARCH OpenAccess CopynumbergainofMYCNgeneisarecurrent geneticaberrationandfavorableprognostic factorinChinesepediatricneuroblastoma patients MiaoWang1,ChunjuZhou2,RongqinCai1,YongLi1andLipingGong1* Abstract Background:AmplificationofMYCNoncogeneisanestablishedmarkerindicatingaggressivetumorprogressionof neuroblastoma(NBL).ButcopynumberanalysesofMYCNgeneinganglioneuroblastoma(GNBL)and ganglioneuroma(GN)ispoorlydescribedintheliterature.Inthestudy,weevaluatedthecopynumberaberrations ofMYCNgeneinclinicalsamplesofNBLs,GNBLsandGNsandanalyzedth

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Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients.docVIP