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Copy number polymorphisms and anticancer pharmacogenomics
Gamazonetal.GenomeBiology2011,12:R46
/2011/12/5/R46
RESEARCH
OpenAccess
Copynumberpolymorphismsandanticancer
pharmacogenomics
EricRGamazon1,RStephanieHuang2,MEileenDolan2* andNancyJCox1,3*
Abstract
Background:Recentstudieshaveinvestigatedthecontributionofcopynumbervariants(CNVs)todisease
susceptibilityinamultitudeofcomplexdisorders,includingsystemiclupuserythematosus,Crohn’sdisease,and
variousneurodevelopmentaldisorders.RelativelyfewCNVstudies,however,havebeenconductedon
pharmacologicphenotypeseventhoughthesestructuralvariantsarelikelytoplayanimportantrole.We
developedagenome-widemethodt
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