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Correcting for bias in estimation of quantitative trait loci effects
Genet.Sel.Evol.37(2005)501–522
c INRA,EDPSciences,2005
DOI:10.1051/gse:2005013
501
Originalarticle
Correctingforbiasinestimation
ofquantitativetraitlocie?ects
JoelIraW??????,MeitalS?????????,MichaR??
InstituteofAnimalSciences,ARO,TheVolcaniCenter,BetDagan50250,Israel
(Received28February2005;accepted4May2005)
Abstract –Estimatesofquantitative traitloci(QTL)e?ectsderived fromcompletegenome
scansarebiased,ifnoassumptionsaremadeaboutthedistributionofQTLe?ects.Biasshould
bereducedifestimatesarederivedbymaximumlikelihood,withtheQTLe?ectssampledfrom
a known distribution. The parameters of the d
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