Corticosteroids for sepsis registry versus Cochrane systematic review!.docVIP

Annane Critical Care 2010,14:185 /content/14/4/185 CO MMENTA RY Corticosteroids for sepsis: registry versus Cochrane systematic review! Djillali Annane* See related research by Beale et al., /content/14/3/R102 a strong heterogeneity across the studies (I = 53% by 2 Abstract random-e? ects model), which was mainly explained by di? erences in treatment strategies. Indeed, the meta- regression using dose and treatment duration showed that survival bene? t was strongly dependent on the dose of cortico steroids (P = 0.02) - the lower the better - and the dur