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Corticosteroids for severe sepsis an evidence-based guide for physicians
AnnaneAnnalsofIntensiveCare2011,1:7
/content/1/1/7
REVIEW
OpenAccess
Corticosteroidsforseveresepsis:anevidence-
basedguideforphysicians
DjillaliAnnane
Abstract
Septicshockischaracterizedbyuncontrolledsystemicinflammationthatcontributestotheprogressionoforgan
failuresandeventuallydeath.Thereisnowampleevidencethattheinabilityofthehosttomountanappropriate
hypothalamic-pituitaryandadrenalaxisresponseplaysamajorinoverwhelmingsystemicinflammationduring
infections.Proinflammatorymediatorsreleasedintheinflamedsitesopposetotheanti-inflammatoryresponse,an
effectthatmaybereversedbyexogenouscorticostero
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