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APOE status and its association to learning and memory performance in middle aged and older Norwegians seeking assessment for memory deficits.doc

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APOE status and its association to learning and memory performance in middle aged and older Norwegians seeking assessment for memory deficits

Behavioral and Brain Functions BioMedCentral Research Open Access APOE status and its association to learning and memory performance in middle aged and older Norwegians seeking assessment for memory deficits Eike Wehling*1, Astri J Lundervold1, Brit Standnes3, Leif Gjerstad4 and Ivar Reinvang2 Address: 1Department of Biological and Medical Psychology, University of Bergen, Norway, 2Center for the study of human cognition, Department of Psychology, University of Oslo, Norway, 3Department of Neurology, Buskerud Hospital, Drammen, Norway and 4Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway Email: Eike Wehling* - eike.wehling@psybp.uib.no; Astri J Lundervold - astri.lundervold@psybp.uib.no; Brit Standnes - brit.standnes@sb- hf.no; Leif Gjerstad - leif.gjerstad@rikshospitalet.no; Ivar Reinvang - ivar.reinvang@psykologi.uio.no * Corresponding author Published: 31 October 2007 Received: 24 January 2007 Accepted: 31 October 2007 Behavioral and Brain Functions 2007, 3:57 doi:10.1186/1744-9081-3-57 This article is available from: /content/3/1/57 ? 2007 Wehling et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: We examined the hypothesis that deficits in learning, memory, and other cognitive functions are associated with the ε4 allele of the Apolipoprotein E (APOE) gene in a non-demented sample with memory complaints recruited from a population with a high prevalence of this allele. Methods: The study group comprised 70 consecutively referred patients aged 50–75 seeking assessment due to memory complaints. They were screened for dementia, for neurological and psychiatric disease, and for cerebral infarction using Magnet Resonance Imaging (MRI). Participants were cla