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Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors.doc

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Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors

Available online /content/8/6/R391 Research Open Access December 2004 Vol 8 No 6 Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors Michael Eddleston1,2, Andrew Dawson3,4, Lakshman Karalliedde5, Wasantha Dissanayake6, Ariyasena Hittarage6, Shifa Azher7 and Nick A Buckley8 1South Asian Clinical Toxicology Research Collaboration, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, UK 2Department of Clinical Medicine, University of Colombo, Sri Lanka 3Department of Pharmacology, University of Newcastle, Australia 4Department of Clinical Medicine, University of Peradeniya, Sri Lanka 5Medical Toxicology Unit, Guys and St Thomass Hospitals, London, UK 6Anuradhapura General Hospital, North Central Province, Sri Lanka 7Polonnaruwa General Hospital, North Central Province, Sri Lanka 8Department of Clinical Pharmacology and Toxicology, Canberra Clinical School, ACT, Australia Corresponding author: Michael Eddleston, eddlestonm@eureka.lk Received: 20 April 2004 Critical Care 2004, 8:R391-R397 (DOI 10.1186/cc2953) This article is online at: /content/8/6/R391 Revisions requested: 9 July 2004 Revisions received: 1 August 2004 Accepted: 13 August 2004 ? 2004 Eddleston et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/ licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided original work is properly cited. Published: 22 September 2004 Abstract Severe organophosphorus or carbamate pesticide poisoning is an important clinical problem in many countries of the world. Unfortunately, little clinical research has been performed and little evidence exists with which to determine best therapy. A cohort study of acute pesticide poisoned patients was established in Sri Lanka during 2002; so far, more than 2000 pesticide