Early release of high mobility group box nuclear protein 1 after severe trauma in humans role of injury severity and tissue hypoperfusion.docVIP

下载本文档

3
0
约4.35万字
约 10页
2017-05-16 发布于上海
举报
版权申诉

Early release of high mobility group box nuclear protein 1 after severe trauma in humans role of injury severity and tissue hypoperfusion.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Early release of high mobility group box nuclear protein 1 after severe trauma in humans role of injury severity and tissue hypoperfusion

Available online /content/13/6/R174 Research Open Access Vol 13 No 6 Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion Mitchell J Cohen1, Karim Brohi2, Carolyn S Calfee3, Pamela Rahn1, Brian B Chesebro4, Sarah C Christiaans1, Michel Carles4, Marybeth Howard4 and Jean-Fran?ois Pittet4 1The Department of Surgery, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA 2The Royal London Hospital, Whitechapel, London E1 1BB, UK 3The Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94114, USA 4The Department of Anesthesia, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA Corresponding author: Mitchell J Cohen, mcohen@ Received: 22 Jan 2009 Revisions requested: 10 Mar 2009 Revisions received: 5 Jun 2009 Accepted: 4 Nov 2009 Published: 4 Nov 2009 Critical Care 2009, 13:R174 (doi:10.1186/cc8152) This article is online at: /content/13/6/R174 ? 2009 Cohen et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction High mobility group box nuclear protein 1 (HMGB1) is a DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like-receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE). However, whether HMGB1 is released early after trauma hemorrhage in humans and is associated with the development of an inflammatory response and co