Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.docVIP

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Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin.doc

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Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin

Available online /content/7/4/R784 Research article Open Access Vol 7 No 4 Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Karim Raza1,2, Francesco Falciani3, S John Curnow1, Emma J Ross1, Chi-Yeung Lee4, Arne N Akbar5, Janet M Lord1, Caroline Gordon1,2, Christopher D Buckley1,2 and Mike Salmon1 1MRC Centre for Immune Regulation, Division of Immunity and Infection, The University of Birmingham, Birmingham, UK 2Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK 3School of Biosciences, The University of Birmingham, Birmingham, UK 4Department of Radiology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK 5Department of Immunology and Molecular Pathology, Royal Free and University College Medical School, London, UK Corresponding author: Karim Raza, k.raza@bham.ac.uk Received: 30 Jan 2005 Revisions requested: 10 Feb 2005 Revisions received: 2 Mar 2005 Accepted: 7 Mar 2005 Published: 7 Apr 2005 Arthritis Research Therapy 2005, 7:R784-R795 (DOI 10.1186/ar1733) This article is online at: /content/7/4/R784 ? 2005 Raza et al.; licensee BioMed Central Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We undertook the present study to identify immune and stromal processes that are present soon after the clinical onset of rheumatoid arthritis (RA) by assessing a panel of T cell, macrophage, and stromal cell related cytokines and chemokines in the synovial fluid of patients with early synovitis. Synovial fluid was aspirated from inflamed joints of patients with inflammatory a