Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis.docVIP

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Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis.doc

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Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis

Available online /content/9/1/R10 Research article Open Access Vol 9 No 1 Early onset pauciarticular arthritis is the major risk factor for naproxen-induced pseudoporphyria in juvenile idiopathic arthritis Susanne G Sch?d1,2, Andrea Kraus3, Imme Haubitz4, Jiri Trcka1,2, Henning Hamm1 and Hermann J Girschick3 1Department of Dermatology, Venereology and Allergology, University of Würzburg, Josef-Schneider-Str, 97080 Würzburg, Germany 2Department of Dermatology and Venereology, University of Rostock, Augustenstr, 18055 Rostock, Germany 3Department of Pediatrics, Section of Pediatric Rheumatology and Osteology, University of Würzburg, Josef Schneider Str, 97080 Würzburg, Germany 4IT Centre, University of Würzburg, Am Hubland, 97074 Würzburg, Germany Corresponding author: Susanne G Sch?d, susanne.schaed@med.uni-rostock.de Received: 11 Oct 2006 Revisions requested: 1 Dec 2006 Revisions received: 18 Jan 2007 Accepted: 31 Jan 2007 Published: 31 Jan 2007 Arthritis Research Therapy 2007, 9:R10 (doi:10.1186/ar2117) This article is online at: /content/9/1/R10 ? 2007 Sch?d et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Pseudoporphyria (PP) is characterized by skin fragility, blistering and scarring in sun-exposed skin areas without abnormalities in porphyrin metabolism. The phenylpropionic acid derivative taking naproxen was 11.4%. PP was particularly frequent in children with the early-onset pauciarticular subtype of JIA (mean age 4.5 years). PP was associated with signs of disease activity, such as reduced haemoglobin (11.75 g/dl), and increased leucocyte counts (10,400/μl) and erythocyte sedimentation rate (26 mm/hour). Comedications, especially chloroquine intake, appeared to be additional risk